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Lounging around all weekend may weigh heavily on the minds of the health-conscious. But these sedentary stretches may not affect the waistline, provided they’re preceded by a bit of exercise.

A new study from UT Southwestern Medical Center shows neurons in mice that influence metabolism are active for up to two days after a single workout. The research offers new insight into the brain’s potential role in fitness and – in the longer term – may provide a target for developing therapies that improve metabolism.

“It doesn’t take much exercise to alter the activity of these neurons,” said Dr. Kevin Williams, a neuroscientist at UT Southwestern. “Based on our results, we would predict that getting out and exercising even once in a semi-intense manner can reap benefits that can last for days, in particular with respect to glucose metabolism.”