Core & Shared Facilities

The Metabolic Phenotyping Core (MPC) provides state-of-the-art analytical and phenotypical measures to the scientific community both inside and outside UT Southwestern Medical Center.

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Our goal is to expand the scope of techniques available to investigators, standardize key methodologies, and expedite the completion of research on diseases related to metabolic disorders (diabetes and obesity), cancer, aging, neurological disorders, etc.

Chemistry analysis using VITROS MicroSlide™ technology, ELISAs, and magnetic bead mapping multiplex technology
Tissue extraction of cholesterol and triglyceride level
Temperature regulated metabolic chambers for indirect gas calorimetry, activity, and food/water consumption
Urine collection chambers
Body composition analysis (MRI )
Glucose-insulin clamp studies
Seahorse XF-24
Extracellular Flux Analyzer for cellular metabolism studies
Primary hepatocyte and β-cell isolation from mice or rats
Sphingolipid profiling using LC-MS/MS technology
Free Amino Acid profiling using LC-MS/MS technology. For Metabolic preclinical and clinical studies (Not for diagnosis purposes)
Exercise treadmills for mice and rats
RNAScope and BaseScope Hybridization