Repa Lab
We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.
Read About us in the news
Some of our major ongoing thematic projects are listed here:
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Eating, Obesity, and Exercise
We have demonstrated key roles for the hormone ghrelin in reward-based eating, stress-induced comfort food eating, and responses to exercise. Ongoing studies aim to identify the CNS sites and mechanisms by which the ghrelin system affects eating, body weight, and exercise and how the components of the ghrelin system contribute to obesity, cachexia, and Prader-Willi Syndrome.
Diabetes and Hypoglycemia
Ghrelin is critical in defending against marked hypoglycemia and death under conditions of marked calorie restriction. Ongoing studies in the lab investigate the CNS and peripheral sites and pathways responsible for the ghrelin system’s blood glucose-related actions in conditions such as diabetes and hypoglycemia.
Secretion of Ghrelin and other Stomach Hormones
We are using a one-of-a-kind set of tools to study the mechanisms directing ghrelin secretion and the physiology of gastric endocrine cells in several different metabolic settings.
Ghrelin, Stress, and Depression
Our group has demonstrated protective, anti-depressant-like actions and food reward-stimulating actions for the ghrelin system under conditions of chronic psychosocial stress. We have identified adult hippocampal neurogenesis as a mechanism for this anti-depressant-like effect of ghrelin.
Berglund Lab
Details about Our Research
Milestones
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Current Lab Members
Name
Title
Sherri Osborne-Lawrence, M.S.
Senior Research Scientist and Lab Manager
Sherri was born in Texas and has lived here all of her life. She received her B.A. degree in Biology from Austin College in Sherman, TX, and an M.S. degree in Molecular & Cell Biology from UT Dallas. She has worked in five laboratories at UT Southwestern Medical Center. Sherri's initial research projects involved positional cloning of genes involved in rheumatoid arthritis and early-onset familial breast cancer. After a few years assisting with the final stages of sequencing for the Human Genome Project, she focused on discovering how endothelial cell dysfunction leads to cardiovascular disease, with particular interests in estrogen modulation as well as the effects of C-reactive protein. Sherri joined the Zigman Lab in 2006 as Senior Research Scientist and Lab Manager, and has now expanded her interests to include ghrelin and its effects on metabolic pathways. Among many other contributions, Sherri has designed and generated several new mouse lines currently in use in the lab and by our collaborators.
Name
Title
Sherri Osborne-Lawrence, M.S.
Senior Research Scientist and Lab Manager
Sherri was born in Texas and has lived here all of her life. She received her B.A. degree in Biology from Austin College in Sherman, TX, and an M.S. degree in Molecular & Cell Biology from UT Dallas. She has worked in five laboratories at UT Southwestern Medical Center. Sherri's initial research projects involved positional cloning of genes involved in rheumatoid arthritis and early-onset familial breast cancer. After a few years assisting with the final stages of sequencing for the Human Genome Project, she focused on discovering how endothelial cell dysfunction leads to cardiovascular disease, with particular interests in estrogen modulation as well as the effects of C-reactive protein. Sherri joined the Zigman Lab in 2006 as Senior Research Scientist and Lab Manager, and has now expanded her interests to include ghrelin and its effects on metabolic pathways. Among many other contributions, Sherri has designed and generated several new mouse lines currently in use in the lab and by our collaborators.
Name
Title
Sherri Osborne-Lawrence, M.S.
Senior Research Scientist and Lab Manager
Sherri was born in Texas and has lived here all of her life. She received her B.A. degree in Biology from Austin College in Sherman, TX, and an M.S. degree in Molecular & Cell Biology from UT Dallas. She has worked in five laboratories at UT Southwestern Medical Center. Sherri's initial research projects involved positional cloning of genes involved in rheumatoid arthritis and early-onset familial breast cancer. After a few years assisting with the final stages of sequencing for the Human Genome Project, she focused on discovering how endothelial cell dysfunction leads to cardiovascular disease, with particular interests in estrogen modulation as well as the effects of C-reactive protein. Sherri joined the Zigman Lab in 2006 as Senior Research Scientist and Lab Manager, and has now expanded her interests to include ghrelin and its effects on metabolic pathways. Among many other contributions, Sherri has designed and generated several new mouse lines currently in use in the lab and by our collaborators.
Name
Title
Sherri Osborne-Lawrence, M.S.
Senior Research Scientist and Lab Manager
Sherri was born in Texas and has lived here all of her life. She received her B.A. degree in Biology from Austin College in Sherman, TX, and an M.S. degree in Molecular & Cell Biology from UT Dallas. She has worked in five laboratories at UT Southwestern Medical Center. Sherri's initial research projects involved positional cloning of genes involved in rheumatoid arthritis and early-onset familial breast cancer. After a few years assisting with the final stages of sequencing for the Human Genome Project, she focused on discovering how endothelial cell dysfunction leads to cardiovascular disease, with particular interests in estrogen modulation as well as the effects of C-reactive protein. Sherri joined the Zigman Lab in 2006 as Senior Research Scientist and Lab Manager, and has now expanded her interests to include ghrelin and its effects on metabolic pathways. Among many other contributions, Sherri has designed and generated several new mouse lines currently in use in the lab and by our collaborators.
Former Lab Members
Tianya Liu, Visiting Graduate student, Suzhou University
Zhuo Deng, Visitng Graduate student in Xi’an Jiaotong University School of Medicine in Xi’an, China
Yong Gao,M.S., Ph.D. Candidate, CAMS & PUMC in Beijing, China
Ting Yao, M.S., Ph.D. Candidate, Xi’an Jiaotong University School of Medicine in Xi’an, China
Jia Sun, M.D., Ph.D., Visiting Associate Professor, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Yiru Huang M.D., Ph.D. Candidate, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Min Yi M.D., Visiting Senior Researcher, Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Jianhong Cao, Visiting Graduate Student, PI-WEI Institute, Guangzhou University of Chinese Medicine, Guangzhou, China
Zhenyan He, M.D. Visiting Senior Researcher, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Sadia Afrin M.S., Research Assistant I
Available Positions
Available Student, Postdoctoral fellow, and Research Technician Positions
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